Impact of previous glucocorticoid therapy on diagnostic accuracy of [18F] FDG PET-CT in giant cell arteritis.

OBJECTIVE: To evaluate the impact of prior glucocorticoid (GC) treatment on the diagnostic accuracy of 18F-FDG PET-CT in giant cell arteritis (GCA). METHODS: Retrospective study of a consecutive cohort of 85 patients with proven GCA who received high-dose GC before PET-CT. RESULTS: Thirty-nine patients previously treated with methylprednisolone (MP) boluses, of whom 37% were PET-CT (uptakes grade 3 or 2) positive. The positivity rate was 80% with MP doses of 125 mg, 33% with 250 or 500 mg, and 0% with doses of 1 g.  If we also classify as positive those cases with a grade 1 uptake (with a circumferencial uptake and smooth linear or long segmental pattern, possibly indicative of "apparently inactive" vasculitis), the positivity rate increases to 62% (100%, 50-60%, and 33% for the different MP doses, respectively). In patients with new-onset GCA treated with high-dose oral GC, PET-CT positivity was 54.5% in patients treated for less than two weeks, 38.5% in those treated for 2 to 4 weeks, and 25% in those treated for 4 to 6 weeks (increasing to 91%, 77%, and 50%, respectively, if we include cases with grade 1 uptake and these characteristics). In patients with relapsing/refractory GCA, or who developed GCA having a prior history of PMR, PET-CT positivity reached 54% despite long-term treatment with low-to-moderate doses of GC (68% including cases with a grade 1 uptake). CONCLUSION: A late 18F-FDG PET-CT (beyond the first 10 days of treatment) can also be informative in a considerable percentage of cases.

Inflammatory pseudotumour of the infratemporal fossa visualized with 18F-FDG PET/CT.

The inflammatory pseudotumour of the head and neck is a benign lesion, extremely rare outside the cranial orbits. A case is presented of an inflammatory pseudotumour not associated with the IgG4-related disease. The pseudotumour was found as a solitary mass in the infratemporal fossa of a young woman who complained of otalgia and hearing loss. A clear image of the lesion was obtained using an 18F-fluoro-deoxy-glucose (18F-FDG) PET. After the histopathological diagnosis, and treatment with corticosteroids, a second 18F-FDG PET was performed. The metabolic image had returned to normal, and the previously observed mass disappeared. A brief review is presented of the studies examining this type of lesion.

Levofloxacin versus azithromycin for treating legionella pneumonia: a propensity score analysis.

OBJECTIVES: Concerns have arisen regarding the equivalence of levofloxacin and some macrolides for treating community-acquired legionella pneumonia (LP). We aimed to compare the outcomes of current patients with LP treated with levofloxacin, azithromycin and clarithromycin. METHODS: Observational retrospective multicentre study of consecutive patients with LP requiring hospitalization (2000-2014) conducted in two hospitals. The primary outcome assessed was 30-day mortality. To control for confounding, therapy was assessed by multivariate analysis. RESULTS: We documented 446 patients with LP, of which 175 were treated with levofloxacin, 177 with azithromycin and 58 with clarithromycin. No significant differences in time to defervescence (2 (interquartile range (IQR) 1-4) versus 2 (IQR 1-3) days; p 0.453), time to achieve clinical stability (3 (2-5) versus 3 (2-5) days; p 0.486), length of intravenous therapy (3 (2-5.25) versus 4 (3-6) days; p 0.058) and length of hospital stay (7 (5-10) versus 6 (5-9) days; p 0.088) were found between patients treated with levofloxacin and those treated with azithromycin. Patients treated with clarithromycin had longer intravenous antibiotic treatment (3 (2-5.25) versus 5 (3-6.25) days; p 0.002) and longer hospital stay (7 (5-10) versus 9 (7-14) days; p 0.043) compared with those treated with levofloxacin. The overall mortality was 4.3% (19 patients). Neither univariate nor multivariate analysis showed a significant association of levofloxacin versus azithromycin on mortality (4 (2.3%) versus 9 (5.1%) deaths; p 0.164). The results did not change after incorporation of the propensity score into the models. CONCLUSIONS: In our study, no significant differences in most outcomes were found between patients treated with levofloxacin and those treated with azithromycin. Due to the small number of deaths, results regarding mortality should be interpreted with caution.

Variability in the prevalence of premenstrual asthma.

Our aim is to analyse the differences in the prevalence of premenstrual asthma (PMA) according to a set of criteria, the relationship between them and the influence of asthma severity. The answer "Yes" to "Does your asthma get worse before menstruation?" was considered subjective PMA. A daily respiratory symptoms register of fertile asthmatic females was taken during two consecutive menstrual cycles. For the semi-objective diagnosis, an exacerbation of > or =20% was required in the symptoms register. Objective diagnosis was a premenstrual worsening of > or =20% of peak flow. We selected 103 patients. Subjective premenstrual deterioration was perceived in 43.7%. The semi-objective deterioration of symptoms in the first cycle occurred in 44.7%, and in 22.3% in both cycles. A total of 54.3% of females with semi-objective criteria in the first cycle perceived a subjective deterioration of symptoms, versus 35.1% of those without semi-objective criteria (p = 0.05). PMA was present at all levels of asthma severity, with no clear link to the degree of severity. The detection of PMA prevalence, the subjective perception of this deterioration and its presence at all levels of asthma severity lead us to urge research into possible premenstrual deterioration in all fertile asthmatic females.

Documento de consenso sobre asma bronquial en Andalucía / No disponible

No disponible

Asma premenstrual, relación con la severidad del asma y su apreciación subjetiva / Premenstrual Asthma, relation between the severity of the asthma and its subjective appreciation

Introducción: diversos estudios, aunque con resultados dispares, han relacionado el asma premenstrual (AP) con la severidad delasma. Por otra parte, no existe uniformidad respecto al hecho de que las pacientes con AP manifiesten una percepción subjetiva de empeoramiento de su asma en el periodo premenstrual. Objetivo: estudiar en mujeres asmáticas, con o sin criterios de AP, la relación con la clasificación del asma (GINA 2005) y el hecho de manifestar un empeoramiento de su asma en el periodo premenstrual. Material y método: se ha realizado un estudio observacional trasversal sobre una población de mujeres asmáticas en edad fértil en las que se realizó un cuestionario en el que se recogía, entre otros aspectos, la clasificación del asma (GINA 2005) y el hecho de manifestar un empeoramiento de los síntomas asmáticos en el periodo premenstrual. Por otra parte, se recogía diariamente durante un ciclo menstrual completo un cuestionario de síntomas respiratorios–SR– (tos, disnea, sibilancias y opresión torácica) y los valores depeak flow (PF) matutino y vespertino durante dicho ciclo. Se considera AP al empeoramiento > 20% en el PF y/o en los síntomas asmáticos (>20%) en el periodo premenstrual. Resultados: hasta el momento, han completado la recogida de los cuestionarios y los valores de PF, en los distintos hospitales participantes,82 pacientes. (6 graves, 29 moderados, 26 persistentes leves y 21 intermitentes leves). De ellas, 35 (42,7%; IC 95%: 31,96-53,41) presentaban criterios clínicos de asma premenstrual. Presentaban criterios funcionales 3 de las mujeres (3,7%), cumpliendo todas ellas también criterios clínicos. El asma premenstrual se distribuyó con frecuencia similar en los distintos grupos de gravedad(p=0,98). Las mujeres con AP reconocían con mayor frecuencia(61,8% frente a 40,4%) el empeoramiento premenstrual de sus síntomas (p=0,06).(..) (AU)

Introduction: A number of studies, although with incongruent results, have related premenstrual asthma (PA) to the severity of the asthma. On the other hand, there is no uniformity regarding the fact that patients with PA express a subjective perception of a worsening of their asthma during the premenstrual period. Objective: To study asthmatic women with/without PA criteria, the relationship between the classification of the asthma (GINA2005) and whether there is a worsening of their asthma during the premenstrual period. Materials and method: A transverse observational study was carried out on a population of fertile, asthmatic women, who completed a questionnaire in which included, amongst other aspects, the asthma classification (GINA 2005) and whether there was a manifest worsening of the asthmatic symptoms during the premenstrual period. On the other hand, a questionnaire of respiratory symptoms (RS), including cough, dyspnea, sibilance and thoracic oppression, was completed daily, during a complete menstrual cycle, plus the Peak Flow values in the morning and evening during this cycle. PA is consider edif there is a worsening >20% during the PF and/or in the asthmatic symptoms (>20%) during the premenstrual period. Results: Up to now, the completed questionnaires have been collected and the values of the Peak Flow (PF), at the different participating hospitals, 82 patients (6 serious, 29 moderate, 26 persistent light and21 intermittent light). Of these, 35 (42.7%; IC95%: 31.96-53.41) presented clinical criteria of Premenstrual Asthma. Three of the women presented functional criteria (3.7%), all them also fulfilling clinical criteria. Premenstrual asthma was distributed with a similar frequently in the different groups of seriousness (p=0.98). The women with PA recognized with more frequency (61.8% as against 40.4%) the premenstrual worsening of their symptoms (p=0.06). (..) (AU)

Cambios en la prevalencia de síntomas de asma e hiperreactividad bronquial en el seguimiento de dos cohortes poblacionales de la ciudad de Huelva / Changes in the prevalence of asthma symptoms and bronchial hyper-reactivity in the follow-up of two population groups of the Huelva city

Objetivo: Analizar los cambios en la prevalencia de síntomas asmáticos e hiperreactividad bronquial (HB) que ocurren con la edad en dos cohortes de adolescentes y adultos jóvenes de la ciudad de Huelva. Material y métodos: Se ha realizado una segunda evaluación en el seguimiento de las dos poblaciones estudiadas entre 1991 y1993: jóvenes adolescentes de 11 a 16 años (n= 714), incluidos en el Estudio de Enfermedades Respiratorias de Huelva (EERH-I), y adultos jóvenes de 20-44 años (n=271), incluida en el Estudio Europeo de Enfermedades Respiratorias (ECRHS-I) de la ciudad de Huelva, a las que se realizaron cuestionario de síntomas respiratorios(SR) y prueba de hiperreactividad bronquial inespecífica con metacolina (MT). En la segunda evaluación, realizada con un seguimiento promedio de 9 años, se consiguió estudiar a 401 de los “niños - adolescentes” y 204 de los “adultos jóvenes”. Al igual que en la fase previa, se ha realizado en ambas población es el mismo cuestionario sobre síntomas respiratorios, una espirometría y una prueba de provocación bronquial inespecífica con metacolina. Se comparan las prevalencias de sibilancias (Sib), HB y asma encontradas en la misma población (niños o adultos), en ambos cortes trasversales (1991 y 2.001). Se comparan los resultados obtenidos entre ambas poblaciones. Resultados: Entre los años 1991 a 2001, tanto en jóvenes como en adultos, se incrementan los síntomas respiratorios, especialmente las sibilancias y la disnea, en reposo y al ejercicio. La hiperreactividad bronquial se incrementa claramente en los jóvenes(p<0.001) y sólo ligeramente en los adultos (NS). Como consecuencia de lo anterior, el diagnóstico epidemiológico de asma (sibilancias+ HB) se incrementó de forma significativa sólo en los jóvenes. Otro dato destacable en los niños era que recibían tratamiento para el asma sólo la mitad de los que estaban diagnosticados de asma por un médico y que éstos eran menos que los que referían haber tenido sibilancias en los últimos 12 meses. La discrepancia entre sibilancias y diagnóstico de asma era más evidente en adultos. Conclusiones: En la década de los 90 y en la ciudad de Huelva, una ciudad con elevada prevalencia de sibilancias (Sib) y nivel medio-bajo de hiperreactividad bronquial (HB) y asma, los SR y la HB se van incrementando durante la adolescencia y se estabilizan en la edad adulta. Esto podría explicarse tanto por la historia natural de la enfermedad como por la diferente influencia de las condiciones ambientales en las diferentes edades

Objective: To analyze the changes in the prevalence of asthmatic symptoms and bronchial hyper-reactive (BHR) conditions, which occur with age, in two groups of adolescents and young adults from the city of Huelva. Material and Methods: A second follow-up evaluation was performed on the two populations studied between 1991 and 1993:adolescents between 11 and 16 years of age (n = 714), included in the Study of Breathing Illnesses of Huelva (EERH-I), and young adults 20-44 years old (n=271), included in the European Study of Breathing Illnesses (ECRHS-I) of the city of Huelva. A questionnaire about breathing symptoms (BS) and a non-specific test of bronchial hyper-reactivity with methacholine (MT) were administered. In the second evaluation, carried out with an average follow up of 9 years, it was possible to study 401 of those “child-adolescents” and 204 of those “young adults.” The same as in the previous phase, both populations were administered the same questionnaire about breathing symptoms, aspirometry and a non-specific bronchial provocation test with methacholine was performed. The prevalence of wheezing, BHR and asthma found in the same population (children or adults) was compared in both cross samples (1991 and 2001). The results obtained were compared between both populations. Results: Between the years 1991 and 2001, both in adolescents and adults, the breathing symptoms increased, especially wheezing and dyspnea, at rest and at exercise. Bronchial hyper-reactivity had a clear increase in the adolescents (p < 0.001) and only a slight increase in the adults (NS). As a consequence of the above, the epidemiologic diagnosis of asthma (wheezing + BHR) increased significantly in adolescents. Another outstanding fact in the children was that only half of those medically diagnosed with asthma received treatment for their asthma, and amongst these, there were fewer that said they had experienced wheezing in the last 12 months. The discrepancy between wheezing and the diagnosis of asthma was more evident in adults. Conclusions: In the 90s and in the city of Huelva, a city with a high prevalence of wheezing and medium-low level of bronchial hyper-reactivity (BHR) and asthma, BS and the HR have increased during adolescence and stabilized in adulthood. This could be explained both by the natural evolution of the disease and by the different influences of the environmental conditions at the different ages

Causa inusual de tos crónica / Unusual cause of chronic cough

La tos crónica es un problema frecuente y tachado de idiopático en bastantes ocasiones al olvidar que su causa puede estar fuera de la vía aérea.Con nuestro caso ponemos de manifiesto que el estudio de la tos crónica no es fácil y que a veces es necesario ampliar las posibilidades más allá de las causas más habituales, recurriendo a los estudios complementarios.Con este objetivo presentamos a una paciente con implantación de placa de titanio a nivel cervical y que presentaba tos crónica que no respondía a tratamientos antitusígeno y antirreflujo. La pruebas de imagen en este caso son cruciales para el diagnóstico, pudiendo visualizar como el tejido blando desarrollado como respuesta inflamatoria a nivel retrofaríngeoes causa de la sintomatología

Chronic cough is a frequent problem that is labeled as idiopathic quite often when it is overlooked that its cause may be outside of the airways.With our case, we manifest that the study of chronic cough is not easy and that it is sometimes necessary to expand the possibilities beyond the most usual causes, resorting to complementary studies.With this objective, we present the case of a patient with a titanium plaque implantation on the cervical level who had chronic cough that did not respond to anti-cough and anti-reflex treatments. The imaging tests in this case are crucial for the diagnosis, it being possible to visualize how the soft tissue developed as an inflammatory response on the retropharyngeal level is the cause of the symptoms

El alga marina Sargassum (Sargassaceae): una alternativa tropical para la alimentación de ganado caprino / The seaweed Sargassum (Sargassaceae) as tropical alternative for goats’ feeding

The nutritive value of seaweed (Sargassum spp.) was studied in Baja California Sur, Mexico. Twenty female Nubian goats (43-weeks old) were randomly distributed into two groups of 10 goats each and were housed in individual pens. One group was fed with a control diet and the other with a diet supplemented with 25% of Sargassum spp. Feed and water intake were recorded daily and individually for 60 days. The weight of each goat was recorded every 15 days. The nutritional content of Sargassum spp. was 89% dry mater, 8% crude protein, 31% ash, 2% ether extract, and 39% carbohydrates. Fiber fractions, minerals, vitamins, fatty acids, and antinutritional factors were also determined. There were no significant differences in body weight (8.6 kg control and 9 kg experimental), feed intake (1.3 kg control and 1.6 kg experimental), and feed conversion rate (11.1 control and 12.6 experimental). Water consumption was greater in the goats that ate the Sargassum diet (5.3 l). From these results,Sargassum spp.can be considered as an alternative feedstuff for goats.

Se estudió el valor nutricional de varias algas del género Sargassum. Veinte cabras hembras (Nubia) en crecimiento (43 semanas)se distribuyeron aleatoriamente en dos grupos de 10 cabras y se alojaron en corraletas individuales. Un grupo fue alimentado con una dieta testigo elaborada con insumos regionales y el otro con una dieta que incluyó el 25% de Sargassum spp. Durante 60 días se midieron diariamente y en forma individual, el alimento y agua consumidos, el peso corporal se cuantificó cada 15 días. La composición química proximal de Sargassum fue de: 89% materia seca, 7.7% proteína, 31% cenizas, 2% extracto etéreo y 39% de carbohidratos. También se determinaron las fracciones de fibra, minerales, vitaminas, ácidos grasos y factores antinutricios. No se encontraron diferencias significativas en el peso corporal (8.6 kg grupo control y 9 kg experimental), alimento consumido (1.31 kg grupo control y 1.6 experimental)y tasa de conversión alimenticia (11.1 grupo control y 12.6 experimental) entre los tratamientos. El consumo de agua fue mayor en el grupo alimentado con la dieta que incluyó Sargassum spp (5.1 l). De los resultados se deduce que las algas marinas de este género pueden ser utilizadas como un forraje alternativo de mediana calidad para el ganado caprino.

[The seaweed Sargassum (Sargassaceae) as tropical alternative for goats' feeding]. / El alga marina Sargassum (Sargassaceae): una alternativa tropical para la alimentación de ganado caprino.

The seaweed Sargassum (Sargassaceae) as tropical alternative for goats' feeding. The nutritive value of seaweed (Sargassum spp.) was studied in Baja California Sur, Mexico. Twenty female Nubian goats (43-weeks old) were randomly distributed into two groups of 10 goats each and were housed in individual pens. One group was fed with a control diet and the other with a diet supplemented with 25% of Sargassum spp. Feed and water intake were recorded daily and individually for 60 days. The weight of each goat was recorded every 15 days. The nutritional content of Sargassum spp. was 89% dry mater, 8% crude protein, 31% ash, 2% ether extract, and 39% carbohydrates. Fiber fractions, minerals, vitamins, fatty acids, and antinutritional factors were also determined. There were no significant differences in body weight (8.6 kg control and 9 kg experimental), feed intake (1.3 kg control and 1.6 kg experimental), and feed conversion rate (11.1 control and 12.6 experimental). Water consumption was greater in the goats that ate the Sargassum diet (5.3 1). From these results, Sargassum spp. can be considered as an alternative feedstuff for goats.

Inmunoterapia y asma / No disponible

No disponible

[Radiographic staging and bronchoalveolar lavage cell counts in sarcoidosis]. / Estadios radiológicos y lavado broncoalveolar en la sarcoidosis.

OBJECTIVE: Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology that mainly affects the lungs and lymph nodes. Bronchoalveolar lavage (BAL) is known to be useful in diagnosis of the disease but its value as a prognostic marker is unclear. The aim of this study was to assess whether there is a characteristic pattern in BAL cell counts according to radiographic stage and determine whether BAL offers information on disease course. PATIENTS AND METHODS: The study included 34 patients with untreated sarcoidosis. Data were collected on the following variables: age, sex, smoking habit, treatment type, radiographic stage, respiratory function, serological parameters, and BAL cell counts. The patients were classified into 3 groups according to functional and radiographic change at 12-month follow-up. RESULTS: No differences in age, sex, or smoking habit were found according to either radiographic stage or disease course. Although the proportion of lymphocytes in BAL fluid was higher in radiographic stage I than in stages II and III, the differences were not statistically significant. The differences in BAL cell counts between groups based on disease course were not statistically significant. CONCLUSIONS: No differences were found in the characteristics of BAL fluid according to radiographic stage. The differential cell count in BAL fluid does not appear to predict the course of sarcoidosis in the first 12 months.

Estadios radiológicos y lavado broncoalveolar en la sarcoidosis / Radiographic staging and bronchoalveolar lavage cell counts in sarcoidosis

Objetivo: La sarcoidosis es una enfermedad inflamatoria granulomatosa multisistémica de causa desconocida que afecta principalmente al pulmón y a los ganglios linfáticos. La utilidad del lavado broncoalveolar (LBA) en el diagnóstico es conocida, pero su valor como marcador pronóstico es controvertido. El objetivo de nuestro estudio es evaluar si existe un patrón característico en la celularidad del LBA según el estadio radiológico de presentación y determinar si el LBA aporta información sobre la evolución de la enfermedad. Pacientes y métodos: Se incluyó en el estudio a 34 pacientes con sarcoidosis no tratados. Se recogieron las siguientes variables: edad, sexo, hábito tabáquico, tipo de tratamiento, estadio radiológico, exploración funcional respiratoria, parámetros serológicos y análisis celular del LBA. Se clasificó a los pacientes en 3 grupos según la evolución funcional y radiológica a los 12 meses. Resultados: No se encontraron diferencias entre la edad, el sexo y el hábito tabáquico ni entre los estadios radiológicos ni entre los grupos según evolución. En el estadio radiológico I el recuento porcentual de linfocitos del LBA fue mayor que en los estadios II y III, pero las diferencias no fueron estadísticamente significativas. Las diferencias en el LBA por grupos evolutivos no fueron estadísticamente significativas. Conclusiones: Al analizar las características del LBA según estadios radiológicos no se encontraron diferencias. El recuento diferencial de células en el LBA no parece predecir el curso de la sarcoidosis durante los primeros 12 meses

Objective: Sarcoidosis is a multisystem granulomatous inflammatory disease of unknown etiology that mainly affects the lungs and lymph nodes. Bronchoalveolar lavage (BAL) is known to be useful in diagnosis of the disease but its value as a prognostic marker is unclear. The aim of this study was to assess whether there is a characteristic pattern in BAL cell counts according to radiographic stage and determine whether BAL offers information on disease course. Patients and methods: The study included 34 patients with untreated sarcoidosis. Data were collected on the following variables: age, sex, smoking habit, treatment type, radiographic stage, respiratory function, serological parameters, and BAL cell counts. The patients were classified into 3 groups according to functional and radiographic change at 12-month follow-up. Results: No differences in age, sex, or smoking habit were found according to either radiographic stage or disease course. Although the proportion of lymphocytes in BAL fluid was higher in radiographic stage I than in stages II and III, the differences were not statistically significant. The differences in BAL cell counts between groups based on disease course were not statistically significant. Conclusions: No differences were found in the characteristics of BAL fluid according to radiographic stage. The differential cell count in BAL fluid does not appear to predict the course of sarcoidosis in the first 12 months

Eritrodermia ictiosiforme congénita ampollosa / No disponible

La eritrodermia ictiosiforme congénita ampollosa (EICA) es una anomalía congénita de la queratinización que se presenta en el momento del nacimiento o poco después del mismo. Entre las características clínicas de esta dermatosis destaca el eritema, la descamación y la aparición de ampollas subcórneas que rápidamente se rompen, dejando áreas erosivas, especialmente en superficies de roce, donde estas lesiones se vuelven vegetantes y pueden sobreinfectarse. Se presenta un caso de EICA en un varón de 8 meses de edad sin antecedentes familiares (AU)

Congenital bullous ichthyosiform erythroderma (CBIE) is a keratinization congenital disorder that appear at the moment of the birth or in first months of life. Clinical features include erythema, desquamation, and subcorneous bulla formation. These bulla quickly break, leaving erosive areas, especially in friction surfaces where these lesions become vegetants and overinfected. A case of CBIE in a male of 8 months old without family antecedents was presented (AU)

Algas marinas de Baja California Sur, México: valor nutrimental / Marine algae of Baja California Sur, Mexico: nutritional value

The Baja California Peninsula is one of the richest regions of seaweed resources in México. The objective of this study was to determine the chemical composition of some marine algae species of Baja California Sur, with an economical potential due to their abundance and distribution, and to promote their use as food for human consumption and animal feeding. The algae studied were Green (Ulva spp., Enteromorpha intestinalis, Caulerpa sertularoides, Bryopsis hypnoides), Red (Laurencia johnstonii, Spyridia filamentosa, Hypnea valentiae) and Brown (Sargassum herporizum, S. sinicola, Padina durvillaei, Hydroclathrus clathrathus, Colpomenia sinuosa). The algae were dried and ground before analysis. In general, the results showed that algae had a protein level less than 11 per cent, except L. johnstonii with 18 per cent and low energy content. The ether extract content was lower than 1 per cent. However, the algae were a good source of carbohydrates and inorganic matter.

Paniculitis eosinofílica: a propósito de uncaso / Eosinophyllic paniculitis: report of a case

La paniculitis eosinofílica se caracteriza por una infiltración prominente de eosinófilos en el tejido celular subcutáneo. Ha sido descrita en pacientes con una gran variedad de cuadros clínicos.Presentamos el caso de una mujer de 40 años de edad con nódulos en el muslo derecho cuya biopsia fue informada de paniculitis eosinofílica (AU)